Constituents of the argentinian medicinal plant Baccharis grisebachii and their antimicrobial activity.

G. E. FERESIN; A. TAPIA; A GIMENEZ; A GUTIÉRREZ RAVELO; S ZACCHINO; M SORTINO; G SCHMEDA-HIRSCHMANN

JOURNAL OF ETHNOPHARMACOLOGY

ELSEVIER

Lugar: Leiden The Netherlands; Año: 2003 vol. 89 p. 73 - 80

0378-8741

The resinous exudate of Baccharis grisebachii which is used to treat ulcers, burns, and skin sores in Argentina showed activity towards dermatophytes and bacteria. Two diterpenes, eight p-coumaric acid derivatives, and two flavones were isolated from the exudate and the structures elucidated by spectroscopic methods. 3-Prenyl-p-coumaric acid and 3,5-diprenyl-p-coumaric acid were active towards Epidermophyton floccosum and Trichophyton rubrum with MICs of 50 and 100–125g/ml, respectively. The diterpene labda-7,13E-dien-2,15-diol was active towards Epidermophyton floccosum and Trichophyton rubrum with MICs of 12.5g/ml while the MIC against Microsporum canis and Trichophyton mentagrophytes was 25g/ml. The diterpene was also active towards Microsporum gypseum with a MIC of 50g/ml, and showed inhibition in both Staphylococcus aureus (methicilline resistant and sensible strains) with MICs of 125g/ml. The results support the use of Baccharis grisebachii in Argentinian traditional medicine.