CIBION 24492
CENTRO DE INVESTIGACIONES EN BIONANOCIENCIAS "ELIZABETH JARES ERIJMAN"
Unidad Ejecutora - UE
artículos
Título:
Ruthenium-Catalyzed Peri - and Ortho -Alkynylation with Bromoalkynes via Insertion and Elimination
Autor/es:
KONOVALOV, ANDREY I.; ECHAVARREN, ANTONIO M.; TAN, ERIC; DOREL, RUTH; FERNÁNDEZ, GABRIELA A.
Revista:
ORGANIC LETTERS
Editorial:
AMER CHEMICAL SOC
Referencias:
Lugar: Washington; Año: 2017 vol. 19 p. 5561 - 5564
ISSN:
1523-7060
Resumen:
The alkynylation of naphthols takes place with total regiocontrol at the peri position of the hydroxyl group in the presence of [RuCl2(p-cymene)]2 as the catalyst. This reaction features high functional group tolerance. The related orthoalkynylation of benzoic acids proceeds under similar conditions and also shows wide functional group tolerance. Both reactions proceed through metalation, insertion of the alkyne, and bromide elimination.
