Biomimetic fiber mesh scaffolds based on gelatin and hydroxyapatite nano-rods: Designing intrinsic skills to attain bone reparation abilities

SARTUQUI JAVIER ; GRAVINA NOEL; RIAL RAMON; BENEDINI LUCIANO; YAHIA L'HOCINE; RUSO JUAN M; MESSINA PAULA

COLLOIDS AND SURFACES B-BIOINTERFACES

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2016 vol. 145 p. 382 - 391

0927-7765

Intrinsic material skills have a deep effect on the mechanical and biological performance of bone substitutes, as well as onits associated biodegradation properties. In this work we have manipulated the preparation of collagenous derived fibermesh frameworks to display a specific composition, morphology, open macroporosity, surface roughness and permeabilitycharacteristics. Next, the effect of the induced physicochemical attributes on the scaffold?s mechanical behavior, bonebonding potential and biodegradability were evaluated. It was found that the scaffold microstructure, their inherent surfaceroughness, and the compression strength of the gelatin scaffolds can be modulated by the effect of the cross-linkingagent and, essentially, by mimicking the nano-scale size of hydroxyapatite in natural bone. A clear effect of bioactivehydroxyapatite nano-rods on the scaffolds skills can be appreciated and it is greater than the effect of the cross-linkingagent, offering a huge perspective for the upcoming progress of bone implant technology.