INVESTIGADORES
COLUCCIO LESKOW Federico
artículos
Título:
Toll-like receptor 4 D299G polymorphism in metabolic disorders: a meta-analysis
Autor/es:
BELFORTE FS; COLUCCIO LESKOW FEDERICO; EDGARDO POSKUS; ALBERTO PENAS STEINHARDT
Revista:
MOLECULAR BIOLOGY REPORTS
Editorial:
SPRINGER
Referencias:
Lugar: Berlin; Año: 2012 p. 1 - 6
ISSN:
0301-4851
Resumen:
The toll-like receptor 4 (TLR4) plays a key role
in the activation of innate immune response participating in
the recognition of lipopolysaccharides. Changes in the
innate immune response are involved in the pathogenesis
of some metabolic disorders such as metabolic syndrome
and type 2 diabetes mellitus (Met-S and T2DM). It has
been recently shown the role of gut microbiota in the
perpetuation of both insulin resistance and low-grade
chronic inflammation. Some studies have reported that
TLR4 D299G polymorphism is associated with metabolic
disorders, however results have been inconsistent. Two
recent meta-analyses showed that D299G is associated with
inflammatory bowel disease and gastrointestinal cancers
risk, two pathological states in which the luminal microbial
flora-host cells interaction may be implicated. We con-
ducted a systemic review of the published data considering
all eligible published studies (six studies with 1696 cases
and 3388 controls for D299G) and a meta-analysis was
performed to evaluate the association between TLR4
D299G polymorphism and the risk for metabolic disorders.
Five studies were identified for T2DM: three corresponding
to Caucasian populations and two to mixed populations.
The remaining study analyzed Met-S in a Caucasian pop-
ulation. We observed a significant association between
D299G polymorphism and metabolic disorders (T2DM and
Met-S) risk (OR = 0.566, 95 % CI: 0.347?0.925, p =
0.023) particularly in Caucasians. No association was
found in mixed population subgroup. Our meta-analysis
identified that the AG/GG genotypes of D299G are asso-
ciated with decreased metabolic disorders risk.