INVESTIGADORES
ACEBEDO SofÍa Lorena
artículos
Título:
Syntheses of immunomodulating androstanes and stigmastanes: Comparison of their TNF-a inhibitory activity
Autor/es:
JAVIER A. RAMÍREZ; ANDREA C. BRUTTOMESSO; FLAVIA M. MICHELINI; SOFÍA L. ACEBEDO; LAURA E. ALCHÉ; LYDIA R. GALAGOVSKY
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY.
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 2007 p. 7538 - 7544
ISSN:
0968-0896
Resumen:
In a previous work our group showed that some synthetic stigmastanes may play a role in immune-mediated inflammation. In this paper we report the syntheses of a series of new steroidal compounds derived from dehydroepiandrosterone and stigmasterol, and the evaluation of their in vitro inhibitory activity of the TNF-a production by macrophages. A preliminary qualitative structure?activity relationship was established
