INVESTIGADORES
LUSTIG Livia
artículos
Título:
Role of Type IV collagen in prolactin release from anterior pituitary of male rats. Diaz E.S., Rettori V.,Suescun M. O., Lustig L., Mc Cann S., Denduchis B
Autor/es:
DIAZ, E.S.; RETTORI, V.; SUESCUN, M.O.; LUSTIG, L.; MC CANN, S.; DENDUCHIS, B.
Revista:
ENDOCRINE
Editorial:
HUMANA PRESS INC
Referencias:
Lugar: Totowa, NJ; Año: 2002 vol. 18 p. 185 - 189
ISSN:
0969-711X
Resumen:
We previously demonstrated that laminin, a component of basement membranes, modulates pituitary hormone secretion. In the present study, we evaluated the effect of type IV collagen, another component of this membrane, on the release of prolactin (PRL) by anterior pituitary gland from adult male rats. Hemipituitaries were incubated for 3 h with type IV collagen or antibodies against it and PRL release was studied. Rabbit IgG to type IV collagen at concentrations of 10(-7) - 10(-5) M had a significant stimulatory effect on PRL release, in comparison to normal rabbit serum IgG or medium alone used as controls. Type IV collagen induced a significant inhibitory effect on basal release of PRL at a concentration of 30 microg/mL. A slight decrease in PRL release was detected in thyrotropin-releasing hormone-stimulated hemipituitaries incubated with type IV collagen at all concentrations used. These results suggest that type IV collagen, similar to laminin-1, modulates PRL released from hemipituitaries, in vitro.