D1-D2 dopamine receptor interaction: an in vivo single unit electrophysiological study

MURER MG; RIQUELME LA; TSENG KY; CRISTAL A; SANTOS J; PAZO JH

NEUROREPORT

Cambridge University press

Año: 1997 vol. 8 p. 783 - 787

0959-4965

After intrastriatal administration of selective dopamine receptor agonists only a small percentage of substantia nigra pars reticulata single units showed changes in firing rate (23% after SKF38393 and 17% after quinpirole). After their intrastriatal co-administration, however, or after the application of the non-selective dopamine receptor agonist apomorphine, 72% and 69% of units responded, respectively. This result confirms the participation of the striatum in the phenomenon of D1-D2 receptor interaction, and show that co-activation of both receptor subtypes produced a maximal effect on basal ganglia output nuclei.