INVESTIGADORES
PODHAJCER Osvaldo Luis
artículos
Título:
Matricellular proteins and inflammatory cells: A task force to promote or defeat cancer?
Autor/es:
LLERA AS; GIROTTI MR; BENEDETTI LG; PODHAJCER OL
Revista:
CYTOKINE & GROWTH FACTOR REVIEWS
Editorial:
ELSEVIER SCI LTD
Referencias:
Lugar: Amsterdam; Año: 2010 p. 67 - 76
ISSN:
1359-6101
Resumen:
In the last years it became clear that the tumor microenvironment plays a
major role in neoplastic growth. Proteins secreted either by the
malignant cells or by the tumor-associated stromal cells act as
extracellular signal transductors, orchestrating tumor progression.
Sentinel cells of the innate immune system patrol the different organs
and have proven either to promote tumor growth or induce tumor
suppression. In recent years, members of the matricellular family of
extracellular proteins were shown to be involved in different aspects of
the inflammatory response during tumor development, although in
contradictory ways. In this review we discuss the evidence available up
to date that relates matricellular proteins with the regulation of the
inflammatory response and tumor progression.