Memory consolidation and reconsolidation: Pharmacological and behavioral effects

BARATTI CM; BOCCIA MB; BLAKE MG

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

BRASIL

Lugar: SAN PABLO; Año: 2009 vol. 42 p. 148 - 159

0100-879X

In this article, we will review some behavioral, pharmacological and neurochemical studies from our laboratory on mice, which might contribute to our understanding of the complex processes of memory consolidation and reconsolidation. We discuss the post-training (memory consolidation) and post-reactivation (memory reconsolidation) effects of icv infusions of hemicholinium,a central inhibitor of acetylcholine synthesis, of intraperitoneal administration of L-NAME, a non-specific inhibitor of nitric oxide synthase, of intrahippocampal injections of an inhibitor of the transcription factor NF-κB, and the exposure of mice to a new learning situation on retention performance of an inhibitory avoidance response. All treatments impair long-term memoryconsolidation and retrieval-induced memory processes different from extinction, probably in accordance with the ?reconsolidation hypothesis?.