Nanostructured SBA-15 host applied in ketorolac tromethamine release system

CUSSA, JORGELINA; JUÁREZ, JULIANA M.; GÓMEZ COSTA, MARCOS B.; ANUNZIATA, OSCAR A.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

SPRINGER

Año: 2017 vol. 28 p. 1 - 8

0957-4530

Abstract: The ordered mesoporous silica SBA-15 has been applied in studies of ketorolac tromethamine adsorption and release. The SBA-15 materials with hexagonal and regular structure were obtained using a triblock copolymer Pluronic P123 as a template and TEOS as a silica source. Ketorolac tromethamine was adsorbed into SBA-15 silica nanochannels using ethanol as solvent. The physicochemical and textural properties of SBA-15 and ketorolac tromethamine/SBA-15 were characterized by X-ray diffraction, thermogravimetric analysis, transmission electron microscopy, fourier transform infrared spectroscopy and BET surface studies. Drug release was evaluated by soaking the loaded silica mesoporous material into a solution of HCl (0.1 N) at initial time (0?2 h) and buffer pH 7 at high times at 37 °C under continuous stirring. Oral commercial Keto tablets (Dolten®) and Keto solution (Keto power) were study for the contrast. Release studies were performed in order to evaluate the required therapeutic efficacy. SBA-15 provides significant improvement in the controlled release of ketorolac tromethamine. Graphical Abstract: Release profile of KETO from SBA-15/KETO and control releases. [InlineMediaObject not available: see fulltext.].