INVESTIGADORES
BRODEUR Celine Marie Julie
artículos
Título:
Acute and subchronic toxicity of arsenite and zinc to tadpoles of Rhinella arenarum both alone and in combination.
Autor/es:
J.C. BRODEUR; C.M. ASOREY; A. SZTRUM; J. HERKOVITS
Revista:
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
Referencias:
Año: 2009 vol. 72 p. 884 - 890
ISSN:
1528-7394
Resumen:
The current study evaluated acute and subchronic toxicity of
arsenite (As3+) and zinc (Zn2+) to stage 25 tadpoles of Rhinella
arenarum in both single and joint laboratory exposures. LC50
values obtained for As3+ were elevated and remained within the
range of 46 to 50 mg/L of As3+ between 4 and 17 d of exposure.
Growth of tadpoles was completely inhibited with 30 mg/L of
As3+, demonstrating the presence of ecologically relevant sublethal
effects at concentrations lower than those resulting in lethality.
With respect to Zn2+, a 96-h LC50 value of 2.49 mg/L was
calculated in soft water. Contrary to results obtained for As3+,
LC50 values of Zn2+ gradually decreased with increasing exposure
duration, from 2.49 mg/L at 96 h to 1.30 mg/L after 21 d. In
joint exposures to both metals, the type of interaction observed
between As3+ and Zn2+ was concentration dependent. Lethal
effects of As3+ were mitigated, unaffected, or potentiated by 0.01,
0.1, and 12 mg/L of Zn2+, respectively. However, although 0.01
mg/L of Zn2+ significantly reduced lethality of As3+-exposed tadpoles,
the same concentration of Zn2+ did not help to reverse the
stunt growth of these animals. Further studies need to examine
which are the lowest concentrations As3+ required to reduce
growth and whether Zn2+ serves to antagonize growth effects in
this range of concentrations.3+) and zinc (Zn2+) to stage 25 tadpoles of Rhinella
arenarum in both single and joint laboratory exposures. LC50
values obtained for As3+ were elevated and remained within the
range of 46 to 50 mg/L of As3+ between 4 and 17 d of exposure.
Growth of tadpoles was completely inhibited with 30 mg/L of
As3+, demonstrating the presence of ecologically relevant sublethal
effects at concentrations lower than those resulting in lethality.
With respect to Zn2+, a 96-h LC50 value of 2.49 mg/L was
calculated in soft water. Contrary to results obtained for As3+,
LC50 values of Zn2+ gradually decreased with increasing exposure
duration, from 2.49 mg/L at 96 h to 1.30 mg/L after 21 d. In
joint exposures to both metals, the type of interaction observed
between As3+ and Zn2+ was concentration dependent. Lethal
effects of As3+ were mitigated, unaffected, or potentiated by 0.01,
0.1, and 12 mg/L of Zn2+, respectively. However, although 0.01
mg/L of Zn2+ significantly reduced lethality of As3+-exposed tadpoles,
the same concentration of Zn2+ did not help to reverse the
stunt growth of these animals. Further studies need to examine
which are the lowest concentrations As3+ required to reduce
growth and whether Zn2+ serves to antagonize growth effects in
this range of concentrations.in both single and joint laboratory exposures. LC50
values obtained for As3+ were elevated and remained within the
range of 46 to 50 mg/L of As3+ between 4 and 17 d of exposure.
Growth of tadpoles was completely inhibited with 30 mg/L of
As3+, demonstrating the presence of ecologically relevant sublethal
effects at concentrations lower than those resulting in lethality.
With respect to Zn2+, a 96-h LC50 value of 2.49 mg/L was
calculated in soft water. Contrary to results obtained for As3+,
LC50 values of Zn2+ gradually decreased with increasing exposure
duration, from 2.49 mg/L at 96 h to 1.30 mg/L after 21 d. In
joint exposures to both metals, the type of interaction observed
between As3+ and Zn2+ was concentration dependent. Lethal
effects of As3+ were mitigated, unaffected, or potentiated by 0.01,
0.1, and 12 mg/L of Zn2+, respectively. However, although 0.01
mg/L of Zn2+ significantly reduced lethality of As3+-exposed tadpoles,
the same concentration of Zn2+ did not help to reverse the
stunt growth of these animals. Further studies need to examine
which are the lowest concentrations As3+ required to reduce
growth and whether Zn2+ serves to antagonize growth effects in
this range of concentrations.3+ were elevated and remained within the
range of 46 to 50 mg/L of As3+ between 4 and 17 d of exposure.
Growth of tadpoles was completely inhibited with 30 mg/L of
As3+, demonstrating the presence of ecologically relevant sublethal
effects at concentrations lower than those resulting in lethality.
With respect to Zn2+, a 96-h LC50 value of 2.49 mg/L was
calculated in soft water. Contrary to results obtained for As3+,
LC50 values of Zn2+ gradually decreased with increasing exposure
duration, from 2.49 mg/L at 96 h to 1.30 mg/L after 21 d. In
joint exposures to both metals, the type of interaction observed
between As3+ and Zn2+ was concentration dependent. Lethal
effects of As3+ were mitigated, unaffected, or potentiated by 0.01,
0.1, and 12 mg/L of Zn2+, respectively. However, although 0.01
mg/L of Zn2+ significantly reduced lethality of As3+-exposed tadpoles,
the same concentration of Zn2+ did not help to reverse the
stunt growth of these animals. Further studies need to examine
which are the lowest concentrations As3+ required to reduce
growth and whether Zn2+ serves to antagonize growth effects in
this range of concentrations.3+ between 4 and 17 d of exposure.
Growth of tadpoles was completely inhibited with 30 mg/L of
As3+, demonstrating the presence of ecologically relevant sublethal
effects at concentrations lower than those resulting in lethality.
With respect to Zn2+, a 96-h LC50 value of 2.49 mg/L was
calculated in soft water. Contrary to results obtained for As3+,
LC50 values of Zn2+ gradually decreased with increasing exposure
duration, from 2.49 mg/L at 96 h to 1.30 mg/L after 21 d. In
joint exposures to both metals, the type of interaction observed
between As3+ and Zn2+ was concentration dependent. Lethal
effects of As3+ were mitigated, unaffected, or potentiated by 0.01,
0.1, and 12 mg/L of Zn2+, respectively. However, although 0.01
mg/L of Zn2+ significantly reduced lethality of As3+-exposed tadpoles,
the same concentration of Zn2+ did not help to reverse the
stunt growth of these animals. Further studies need to examine
which are the lowest concentrations As3+ required to reduce
growth and whether Zn2+ serves to antagonize growth effects in
this range of concentrations.3+, demonstrating the presence of ecologically relevant sublethal
effects at concentrations lower than those resulting in lethality.
With respect to Zn2+, a 96-h LC50 value of 2.49 mg/L was
calculated in soft water. Contrary to results obtained for As3+,
LC50 values of Zn2+ gradually decreased with increasing exposure
duration, from 2.49 mg/L at 96 h to 1.30 mg/L after 21 d. In
joint exposures to both metals, the type of interaction observed
between As3+ and Zn2+ was concentration dependent. Lethal
effects of As3+ were mitigated, unaffected, or potentiated by 0.01,
0.1, and 12 mg/L of Zn2+, respectively. However, although 0.01
mg/L of Zn2+ significantly reduced lethality of As3+-exposed tadpoles,
the same concentration of Zn2+ did not help to reverse the
stunt growth of these animals. Further studies need to examine
which are the lowest concentrations As3+ required to reduce
growth and whether Zn2+ serves to antagonize growth effects in
this range of concentrations.2+, a 96-h LC50 value of 2.49 mg/L was
calculated in soft water. Contrary to results obtained for As3+,
LC50 values of Zn2+ gradually decreased with increasing exposure
duration, from 2.49 mg/L at 96 h to 1.30 mg/L after 21 d. In
joint exposures to both metals, the type of interaction observed
between As3+ and Zn2+ was concentration dependent. Lethal
effects of As3+ were mitigated, unaffected, or potentiated by 0.01,
0.1, and 12 mg/L of Zn2+, respectively. However, although 0.01
mg/L of Zn2+ significantly reduced lethality of As3+-exposed tadpoles,
the same concentration of Zn2+ did not help to reverse the
stunt growth of these animals. Further studies need to examine
which are the lowest concentrations As3+ required to reduce
growth and whether Zn2+ serves to antagonize growth effects in
this range of concentrations.3+,
LC50 values of Zn2+ gradually decreased with increasing exposure
duration, from 2.49 mg/L at 96 h to 1.30 mg/L after 21 d. In
joint exposures to both metals, the type of interaction observed
between As3+ and Zn2+ was concentration dependent. Lethal
effects of As3+ were mitigated, unaffected, or potentiated by 0.01,
0.1, and 12 mg/L of Zn2+, respectively. However, although 0.01
mg/L of Zn2+ significantly reduced lethality of As3+-exposed tadpoles,
the same concentration of Zn2+ did not help to reverse the
stunt growth of these animals. Further studies need to examine
which are the lowest concentrations As3+ required to reduce
growth and whether Zn2+ serves to antagonize growth effects in
this range of concentrations.2+ gradually decreased with increasing exposure
duration, from 2.49 mg/L at 96 h to 1.30 mg/L after 21 d. In
joint exposures to both metals, the type of interaction observed
between As3+ and Zn2+ was concentration dependent. Lethal
effects of As3+ were mitigated, unaffected, or potentiated by 0.01,
0.1, and 12 mg/L of Zn2+, respectively. However, although 0.01
mg/L of Zn2+ significantly reduced lethality of As3+-exposed tadpoles,
the same concentration of Zn2+ did not help to reverse the
stunt growth of these animals. Further studies need to examine
which are the lowest concentrations As3+ required to reduce
growth and whether Zn2+ serves to antagonize growth effects in
this range of concentrations.3+ and Zn2+ was concentration dependent. Lethal
effects of As3+ were mitigated, unaffected, or potentiated by 0.01,
0.1, and 12 mg/L of Zn2+, respectively. However, although 0.01
mg/L of Zn2+ significantly reduced lethality of As3+-exposed tadpoles,
the same concentration of Zn2+ did not help to reverse the
stunt growth of these animals. Further studies need to examine
which are the lowest concentrations As3+ required to reduce
growth and whether Zn2+ serves to antagonize growth effects in
this range of concentrations.3+ were mitigated, unaffected, or potentiated by 0.01,
0.1, and 12 mg/L of Zn2+, respectively. However, although 0.01
mg/L of Zn2+ significantly reduced lethality of As3+-exposed tadpoles,
the same concentration of Zn2+ did not help to reverse the
stunt growth of these animals. Further studies need to examine
which are the lowest concentrations As3+ required to reduce
growth and whether Zn2+ serves to antagonize growth effects in
this range of concentrations.2+, respectively. However, although 0.01
mg/L of Zn2+ significantly reduced lethality of As3+-exposed tadpoles,
the same concentration of Zn2+ did not help to reverse the
stunt growth of these animals. Further studies need to examine
which are the lowest concentrations As3+ required to reduce
growth and whether Zn2+ serves to antagonize growth effects in
this range of concentrations.2+ significantly reduced lethality of As3+-exposed tadpoles,
the same concentration of Zn2+ did not help to reverse the
stunt growth of these animals. Further studies need to examine
which are the lowest concentrations As3+ required to reduce
growth and whether Zn2+ serves to antagonize growth effects in
this range of concentrations.2+ did not help to reverse the
stunt growth of these animals. Further studies need to examine
which are the lowest concentrations As3+ required to reduce
growth and whether Zn2+ serves to antagonize growth effects in
this range of concentrations.3+ required to reduce
growth and whether Zn2+ serves to antagonize growth effects in
this range of concentrations.2+ serves to antagonize growth effects in
this range of concentrations.