INVESTIGADORES
MUSSO Carlos Guido
artículos
Título:
Obstructive nephropathy: its physiopathology
Autor/es:
MUSSO, CARLOS GUIDO; NAVARRO, MATILDE; JAUREGUI, RICARDO
Revista:
Rev Electron Biomed
Editorial:
MJ Coma MD, PhD. Unidad de Investigación. Hospital General Yagüe
Referencias:
Año: 2011
Resumen:
Obstructive nephropathy is the functional and /or parenchymal renal damage secondary to the urinary tract occlusion at any part of it. The inducing urinary obstruction diseases can vary depending on the patient´s age and gender.There are many renal dysfunction inducing mechanisms involved in this entity: increase in the intra-luminal pressure, ureteral dilatation with ineffective ureteral peristalsis, glomerular ultrafiltration net pressure reduction, intra-renal glomerular blood flux reduction due to vasoconstriction, and local disease of chemotactic substances. Obstructive nephropathy can also lead tohypertension (vasoconstriction-hypervolemia), hyperkalemia, metabolic acidosis (aldosterone resistance), diabetes insipidus (vasopressine resistance).In conclusion, since obstructive nephropathy is a potentially reversible cause of renal dysfunction, it should always be taken into account among the differential diagnosis of renal failure inducing mechanisms.
