A substituted sulfonamide and its Co (II), Cu (II) and Zn (II) complexes as potential antifungal agents

JORGE DÍAZ; HÉCTOR BALDONI; CLAUDIU T. SUPURAN; MARTÍN A. FERNÁNDEZ BALDO; DANIELA VULLO; GERARDO CAMÍ; GUSTAVO ECHEVERRÍA; DELIA B. SORIA

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

TAYLOR & FRANCIS LTD

Lugar: London; Año: 2016 vol. 31 p. 51 - 62

1475-6366

A sulfonamide 1-tosyl-1-H-benzo(d)imidazol-2-amine (TBZA) and three new complexes of Co(II) , Cu(II) and Zn(II) have been synthesized. The compounds have been characterizedby elemental analyses, FTIR, 1H and 13C-NMR spectroscopy. The structure of the TBZA, andits Co(II) and Cu(II) complexes were determined by X-ray diffraction methods. TBZA and its Co(II) complex crystallizes in the triclinic P-1 space group, while the Cu(II) complexcrystallizes in the monoclinic P21/c space group.Antifungal activity was screened against eight pathogenic yeasts: Candida albicans (DMic972576), Candida krusei (DMic 951705), Candida glabrata (DMic 982882), Candidatropicalis (DMic 982884), Candida dubliniensis (DMic 93695), Candida guillermondii(DMic 021150), Cryptococcus neoformans (ATCC 24067) and Cryptococcus gattii (ATCCMYA-4561). Results on the inhibition of various human (h) CAs, hCA I, II, IV, VII, IX and XII, and pathogenic beta and gamma CAs are also reported.