Elevated extension of longevity by cyclically heat stressing a set of recombinant inbred lines of Drosophila melanogaster throughout their adult life

PABLO SAMBUCETTI; FEDERICO H GÓMEZ; FABIÁN M NORRY

BIOGERONTOLOGY

SPRINGER

Lugar: Berlin; Año: 2016 vol. 17 p. 883 - 892

1389-5729

An extremely high (about 100 %)increase in longevity is reported for a subset of recombinant inbred lines(RILs) of Drosophila melanogaster subjected to a cyclic heat stress throughoutthe adult life. Previous work showed that both longevity and heat sensitivityhighly differed among RILs. The novel heat stress treatment used in this studyconsisted of 5 min at 38°C applicated approximately every 125 min throughoutthe adult life starting at the age of 2 days. In spite of the exceptionallyhigh increase in longevity in a set of RILs, the same heat stress treatmentreduced rather than increased longevity in other RILs, suggesting thatheat-induced hormesis is dependent on the genotype and/or the geneticbackground. Further, one quantitative trait locus (QTL) was identified forheat-induced hormesis on chromosome 2 (bands 28A1-34D2) in one RIL panel(RIL-D48) but it was not significant in its reciprocal panel (RIL-SH2). Thelevel of heat-induced hormesis showed a sexual dimorphism, with a higher numberof lines exhibiting higher hormesis effects in males than in females. The newheat stress treatment in this study suggests that longevity can be furtherextended than previously suggested by applying a cyclic and mild stressthroughout the life, depending on the genotype.