FLOURENSIA FIEBRIGII BLAKE METABOLITES DISRUPT STAPHYLOCOCCUS AUREUS BIOFILM

VERNI C.; ALVA M.; MURUAGA N.; CARTAGENA E.; BARDON A.

BIOCELL

INST HISTOL EMBRIOL-CONICET

Lugar: MENDOZA; Año: 2011 vol. 35 p. 104 - 104

The genus Flourensia DC comprises 25 species distributedthroughout the Americas. The genus is characterized by the occurrenceof bioactive aromatic metabolites. This study describesthe antibiofilm properties of a chloroform extract of aerial partsof F. fiebrigii against two pathogenic strains of Staphylococcusaureus (ATCC 6538 P and methicillin resistant). The disruptionof the biofilm formed by cells phenotypically different from theplanktonic bacteria was measured by a colorimetric method (560nm). The spectroscopic data of the chloroform extract was consistentwith the chemical constituents of F. fiebrigii. Considerabledisrupting effects (60-51%) were observed on the biofilmarchitecture of both strain of S. aureus at 100 μg/mL and 50 μg/mL. These preliminary results open a new path in the search fornatural coadjuvants of antibiotics to increase their bioavailabilityto the resistant bacterial strain.