Morphometric analysis of the parotid gland affected by alcoholic sialosis

BOHL LUCIANA ; MERLO CAROLINA; CARDA CARMEN; GOMEZ DE FERRARIS MARIA ELSA; CARRANZA MIRIAM

JOURNAL OF ORAL PATHOLOGY AND MEDICINE

WILEY-BLACKWELL PUBLISHING, INC

Año: 2008 vol. 37 p. 499 - 503

0904-2512

BACKGROUND: In alcoholic parotid sialosis, the gland is frequently enlarged due to ductal and/or acinar hypertrophy, ductal hyperplasy and stromal fat infiltration. The aim of this study was to determine acinar and ductal dimensions, the number of striated ducts and the proportionof fat tissue in patients with and without alcoholic parotid sialosis.METHODS: Twelve parotid biopsy samples from patients with hepatic alcoholic cirrhosis and those from seven controls were used. A morphometrical study with a digital image analyser attached to an optical microscope was carried out. Direct and indirect indicators from acinar and ductal dimensions were recorded. The number of striated ducts and the proportion of fat tissue in stroma were determined. Fifteen records for each variable were taken. Meanvalues were compared using the Mann Mann-Whitney U-test. RESULTS: There were no significant differences in acinar and ductal dimensions and the number of striated ducts between alcoholic and control patients. The proportion of fat tissue in alcoholic parotides was significantly lower than that in the controls.CONCLUSIONS: These results do not corroborate previous qualitative descriptions about acinar and ductal hypertrophy and ductal hyperplasy in alcoholic patients. The main cause of parotid enlargement could not be stromal fat infiltration. The data could be used for differentialdiagnoses of sialosis.