Comparative and functional triatomine genomics reveal reductions and expansions in insecticide resistance-related gene families

TRAVERSO, LUCILA; ANDRES LAVORE, IVANA SIERRA, VICTORIO PALACIO, JESUS MARTINEZ-BARNETCHE, JOSE MANUEL LATORRE-ESTIVALIS, GASTON MOUGABURE-CUETO, FLAVIO FRANCINI, MARCELO G. LORENZO, MARIO HENRY RODRIGUEZ,; ONS, SHEILA; RIVERA POMAR R

PLOS NEGLECTED TROPICAL DISEASES

PUBLIC LIBRARY SCIENCE

Lugar: San Francisco; Año: 2017

1935-2735

Triatomine insects are vectors of Trypanosoma cruzi, a protozoan parasite that is the causativeagent of Chagas´ disease. This is a neglected disease affecting approximately 8 millionpeople in Latin America. The existence of diverse pyrethroid resistant populations of at leasttwo species demonstrates the potential of triatomines to develop high levels of insecticideresistance. Therefore, the incorporation of strategies for resistance management is a mainconcern for vector control programs. Three enzymatic superfamilies are thought to mediatexenobiotic detoxification and resistance: Glutathione Transferases (GSTs), CytochromesP450 (CYPs) and Carboxyl/Cholinesterases (CCEs). Improving our knowledge of key triatominedetoxification enzymes will strengthen our understanding of insecticide resistance processesin vectors of Chagas´ disease.An additional conclusion is that the SIGEVA interphase is badly designed and it is time consuming. I´ve already spent more than 10 minutes to validate this single paper.