INVESTIGADORES
SPETALE Flavio Ezequiel
artículos
Título:
Formalization of Gene Ontology relationships with factor graph towards Biological Process prediction
Autor/es:
SPETALE FLAVIO EZEQUIEL; BULACIO PILAR; KRSTICEVIC FLAVIA; PONCE SERGIO; TAPIA ELIZABETH
Revista:
IFMBE PROCEEDINGS
Editorial:
Springer Nature Singapore
Referencias:
Lugar: Singapore; Año: 2017 vol. 60 p. 58 - 61
ISSN:
1680-0737
Resumen:
Gene Ontology is a hierarchical controlled vocabulary for protein annotation. Its synergy with automatic classification methods, ensemble, has been widely used for the prediction of protein functions. Current classification methods use only the relation is a and a few little part of to generate prediction model. In this work we formalize the GO part of, regulates; negatively regulates and positively regulates relationships through predicate logic. This formalization is incorporated within an en-semble method based on graph factor called Factor Graph GOAnnotation. The proposed model is validated against four modelorganisms for GO Biological Process prediction.
