INVESTIGADORES
LORENZO PISARELLO Maria Jose
artículos
Título:
MicroRNAs in the Cholangiopathies: Pathogenesis, Diagnosis,and Treatment.
Autor/es:
LORENZO PISARELLO, MARÍA JOSÉ; LOARCA, LORENA; IVANICS, TOMMY; MORTON, LESLIE; LARUSSO, NICHOLAS
Revista:
Journal of Clinical Medicine
Editorial:
MDPI AG
Referencias:
Año: 2015
ISSN:
2077-0383
Resumen:
he cholangiopathies are a group of liver diseases resulting from different etiologies but with the cholangiocyte as the primary target. As a group, the cholangiopathies result in significant morbidity and mortality and represent one of the main indications for liver transplant in both children and adults. Contributing to this situation is the absence of a thorough understanding of their pathogenesis and a lack of adequate diagnostic and prognostic biomarkers. MicroRNAs are small non-coding RNAs that modify gene expression post-transcriptionally. They have been implicated in the pathogenesis of many diseases, including the cholangiopathies. Thus, in this review we provide an overview of the literature on miRNAs in the cholangiopathies and discuss future research directions.
