Extinction and recovery of an avoidance memory impaired by scopolamine.

NAVARRO NICOLAS; KRAWCZYK MC; BOCCIA MM; BLAKE MG

PHYSIOLOGY AND BEHAVIOR

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2017 vol. 171 p. 192 - 198

0031-9384

Pre-training administration of scopolamine (SCP) resembles situations of cholinergic dysfunction, leading to memory impairment of mice trained in an inhibitory avoidance task. We suggest here that SCP does not impair memory formation, but acquisition is affected in a way that reduces the strength of the stored memory, thusmaking this memory less able to control behavior when tested. Hence, a memory trace is stored, but is poorly expressed during the test. Although weakly expressed, this memory shows extinction during successive tests, and can be strengthened by using a reminder. Our results indicate that memories stored under cholinergic dysfunction conditions seemabsent or lost, but are in fact present and experience common memory processes, such as extinction, and could be even recovered by using appropriate protocols.