MONOFLUORINATION METHODS IN DRUG DISCOVERY

POSTIGO J. ALBERTO; YERIEN DAMIAN; BONESI S. M.

ORGANIC & BIOMOLECULAR CHEMISTRY

ROYAL SOC CHEMISTRY

Lugar: CAMBRIDGE; Año: 2016 vol. 14 p. 8398 - 8427

1477-0520

Fluorination reactions of medicinal and biological-active compounds will be discussed. The development of new and improved organic chemistry strategies for fluorination reactions, either applied to specific families of organic compounds, with simple or complex structures, or else directed to the innate fluorination of targets with relevant biological activity, will both have an impact on future protocols and large-scale methodologies that could ultimately be applied to the late-stage fluorination of compounds of interest in medicinal chemistry. The strategies will take into account different families of organic compounds such as (hetero)aromatic rings, and aliphatic substrates (sp3, sp2, and sp carbon atoms). Fluorination strategies will be nucleophilic, electrophilic and of radical nature.