INVESTIGADORES
RAMOS Jorge Guillermo
artículos
Título:
Developmental exposure to bisphenol a alters the differentiation and functional response of the adult rat uterus to estrogen treatment.
Autor/es:
VIGEZZI L; BOSQUIAZZO VL; KASS L; RAMOS JG; MUÑOZ-DE-TORO M; LUQUE EH
Revista:
REPRODUCTIVE TOXICOLOGY (ELMSFORD, N.Y.)
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2015 vol. 0890 p. 12 - 18
ISSN:
0890-6238
Resumen:
We assessed the long-term effect of perinatal exposure to bisphenol A (BPA) on the rat uterus and the uterine response to estrogen (E2) replacement therapy. BPA (0.5 or 50μg/kg/day) was administered in the drinking water from gestational day 9 until weaning. We studied the uterus of female offspring on postnatal day (PND) 90 and 360, and the uterine E2 response on PND460 (PND460-E2). On PND90, BPA-exposed rats showed altered glandular proliferation and α-actin expression. On PND360, BPA exposure increased the incidence of abnormalities in the luminal and glandular epithelium. On PND460-E2, the multiplicity of glands with squamous metaplasia increased in BPA50 while the incidence of glands with daughter glands increased in BPA0.5. The expression of steroid receptors, p63 and IGF-I was modified in BPA-exposed rats on PND460-E2. The long-lasting effects of perinatal exposure to BPA included induction of abnormalities in uterine tissue and altered response to E2 replacement therapy.