Driving CARs into Sweet Roads: Targeting Glycosylated Antigens in Cancer

BLIDNER, ADA G.; MARIÑO, KARINA VALERIA; RABINOVICH, GABRIEL A.

IMMUNITY

CELL PRESS

Lugar: United States; Año: 2016 vol. 44 p. 1248 - 1250

1074-7613

Engineering T cells with chimeric antigen receptors (CARs) has demonstrated remarkable success in eradicating hematological malignancies. In this issue of Immunity, June and colleagues demonstrate the broad antitumor efficacy of a newly-designed CAR targeting the O-linked hypoglycosylated epitopes Tn and sialyl-Tn on cancer-associated MUC-1.(Este articulo es un preview de un articulo original: Posey, A.D., Schwab, R.D., Boesteanu, A.C., Steentoft, C., Mandel, U., Engels, B., Stone, J.D., Madsen, T.D., Schreiber, K., Haines, K.M., et al. (2016). Immunity 44, 1444?1454.)