INVESTIGADORES
ARENA Mario Eduardo
artículos
Título:
Bioactive Sesqui- and Diterpenoids from the Argentine Liverwort
Autor/es:
GILABERT, MIGUEL; RAMOS, ALBERTO; SCHIAVONE, MARIOA; ARENA ME; BARDON
Revista:
JOURNAL OF NATURAL PRODUCTS
Editorial:
AMER CHEMICAL SOC
Referencias:
Año: 2011 vol. 74 p. 574 - 579
ISSN:
0163-3864
Resumen:
Four Fusicoccane-type diterpenoids (1-4), including the new 1 and 2; four pinguisane-type sesquiterpenoids (5-8); and two aromadendrane-type sesquiterpenoids (9 and 10) were isolated from an Argentine collection of the endemic liverwort Porella chilensis. The biofilm formation of the human pathogen Pseudomonas aeruginosa was inhibited by compounds 3 (53 and 47%), 9 (45 and 41%), and 10 (48 and 37%) at 50 and 5 ìg/mL, respectively. Compounds 3, 9, and 10 also produced a slight decrease in bacterial growth and interfere with the process of quorum sensing at the same doses.
