Biomimetic fiber mesh scaffolds based on gelatin and hydroxyapatite nano-rods: designing intrinsic skills to attain bone reparation abilities

JAVIER SARTUQUI; A. NOEL GRAVINA; RAMÓN RIAL; LUCIANO BENEDINI; LHOCINE YAHIAC,; JUAN M RUSO; PAULA V. MESSINA

COLLOIDS AND SURFACES B-BIOINTERFACES

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2016 vol. 145 p. 382 - 391

0927-7765

Intrinsic material skills have a deep effect on the mechanical and biological performance of bone sub-stitutes, as well as on its associated biodegradation properties. In this work we have manipulated thepreparation of collagenous derived fiber mesh frameworks to display a specific composition, morphology,open macroporosity, surface roughness and permeability characteristics. Next, the effect of the inducedphysicochemical attributes on the scaffold?s mechanical behavior, bone bonding potential and biodegrad-ability were evaluated. It was found that the scaffold microstructure, their inherent surface roughness,and the compression strength of the gelatin scaffolds can be modulated by the effect of the cross-linkingagent and, essentially, by mimicking the nano-scale size of hydroxyapatite in natural bone. A clear effectof bioactive hydroxyapatite nano-rods on the scaffolds skills can be appreciated and it is greater than theeffect of the cross-linking agent, offering a huge perspective for the upcoming progress of bone implanttechnology.