Choleretic and antioxidant effect of Eupatorium bunifolium

GORZALCZANY, S.; MUSCHIETTI, L.; REPETTO, M.; KARTIN, L.; FERRARO, G.; MARTINO, V.; ACEVEDO, C.

PHARMACOLOGYONLINE

University of Salerno.

Lugar: Salerno, Italy.; Año: 2008 vol. 1 p. 139 - 147

1827-8620

Eupatorium buniifolium is widely distributed in Argentina and it is used in folk medicine as digestive and in hepato-biliary complaints. The aqueous extract of the aerial parts has been tested in rats for its choleretic, antioxidant activity and acute toxicity effects. The extract showed significant choleretic effect (35%, i.v. and 50%, p.p.) after both oral (500 mg/kg) and intravenous (250 mg/kg) administration without changes in the bile acids output. Measure of Total Reactive Antioxidant Potential (TRAP) and the Total Antioxidant Reactivity (TAR) indicate that the extract has antioxidants such as phenolic and flavonoid compound, extensively reported as free radical scavengers. Toxicity signs were not observed until oral dose of 3000 mg/kg.