The role of cytoskeleton and adhesion proteins in the resistance to photodynamic therapy. Possible therapeutic interventions.

DI VENOSA, GABRIELA; PEROTTI, CHRISTIAN; BATLLE, ALCIRA; CASAS, ADRIANA

Photochemical and Photobiological Sciences

ROYAL SOC CHEMISTRY

Lugar: CAMBRIDGE; Año: 2015 vol. 14 p. 1451 - 1464

1474-905X

It is known that PhotodynamicTherapy (PDT) induces changes in the cytoskeleton, the cell shape, and theadhesion properties of tumour cells. In addition, these targets have also beendemonstrated to be involved in the development of PDT resistance. The reversalof PDT resistance by manipulating the cell adhesion process to substrata hasbeen out of reach. Even though the existence of cell adhesion-mediated PDTresistance has not been reported so far, it cannot be ruled out. In addition toits impact on the apoptotic response to photodamage, the cytoskeletonalterations are thought to be associated with the processes of metastasis andinvasion after PDT. In this review, we will address the impact of photodamageon the microfilament and microtubule cytoskeleton components and its regulatorson PDT-treated cells as well as on cell adhesion. We will also summarise theimpact of PDT on the surviving and resistant cells and their metastaticpotential. Possible strategies aimed at taking advantage of the changes inducedby PDT on actin, tubulin and cell adhesion proteins by targeting thesemolecules will also be discussed.