Postnatal exposure to a progestin does not prevent uterine adenogenesis in domestic dogs

PONCHON T; LOPEZ MERLO M; FAYAL M; PRIOTTO M; BARBEITO C; GOBELLO C

JOURNAL OF VETERINARY SCIENCE

KOREAN SOC VETERINARY SCIENCE

Año: 2016 vol. 17 p. 111 - 113

1229-845X

To assess the effect of a single supraphysiological postnatal administration of a progestagen on uterine glands in dogs, 10 females were randomly assigned to: Medroxyprogesterone acetate 35 mg (MPA; n=6) or Placebo (n = 4) within the first 24 h of birth. The safety of the treatment was also evaluated. A transient mild clitoris enlargement appeared in MPA-treated females. Microscopic postpubertal uterine assessment revealed the presence of uterine glandsin all the cases without significant differences in the area occupied by the glands per µm2 of endometrium nor in the height of the uterine epithelium.