INVESTIGADORES
GOLOMBEK Diego Andres
artículos
Título:
NERVE GROWTH FACTOR-INDUCED CIRCADIAN PHASE SHIFTS AND MAP KINASE ACTIVATION IN THE HAMSTER.
Autor/es:
DIEGO ANDRES GOLOMBEK; A PIZZIO, G; C HAINICH, E; A PLANO, S; M RALPH,
Revista:
EUROPEAN JOURNAL OF NEUROSCIENCE
Referencias:
Año: 2005 vol. 22 p. 665 - 671
ISSN:
0953-816X
Resumen:
Circadian rhythms are entrained by light and by several neurochemical stimuli. In hamsters housed in constant darkness, i.c.v.
administration of nerve growth factor (NGF) at various times in their circadian cycle produced phase shifts of locomotor activity
rhythms that were similar in direction and circadian timing to those produced by brief pulses of light. Moreover, the effect of NGF and
light were not additive, indicating signalling points in common. These points include the immediate-early gene c-fos and ERK1 ⁄ 2, a
component of the mitogen-activated protein kinases (MAPK) family. NGF activates c-FOS and ERK1 ⁄ 2-MAPK in the
suprachiasmatic nuclei, the site of a circadian clock in mammals, when administered during the subjective night but not during
the day. The effect of NGF on ERK1 ⁄ 2 activation was not inhibited by the administration of MK-801, a glutamate ⁄ NMDA receptor
antagonist. These results suggest that NGF, acting through MAPK activation, plays a role in photic entrainment of the mammalian
circadian clock.⁄ 2, a
component of the mitogen-activated protein kinases (MAPK) family. NGF activates c-FOS and ERK1 ⁄ 2-MAPK in the
suprachiasmatic nuclei, the site of a circadian clock in mammals, when administered during the subjective night but not during
the day. The effect of NGF on ERK1 ⁄ 2 activation was not inhibited by the administration of MK-801, a glutamate ⁄ NMDA receptor
antagonist. These results suggest that NGF, acting through MAPK activation, plays a role in photic entrainment of the mammalian
circadian clock.⁄ 2-MAPK in the
suprachiasmatic nuclei, the site of a circadian clock in mammals, when administered during the subjective night but not during
the day. The effect of NGF on ERK1 ⁄ 2 activation was not inhibited by the administration of MK-801, a glutamate ⁄ NMDA receptor
antagonist. These results suggest that NGF, acting through MAPK activation, plays a role in photic entrainment of the mammalian
circadian clock.⁄ 2 activation was not inhibited by the administration of MK-801, a glutamate ⁄ NMDA receptor
antagonist. These results suggest that NGF, acting through MAPK activation, plays a role in photic entrainment of the mammalian
circadian clock.