INVESTIGADORES
GOLOMBEK Diego Andres
artículos
Título:
CONSTITUTIVE ACTIVATION OF THE ERK-MAPK PATHWAY IN THE SUPRACHIASMATIC NUCLEI INHIBITS CIRCADIAN RESETTING
Autor/es:
DIEGO ANDRES GOLOMBEK; G A, PIZZIO; C HAINICH, E
Revista:
FEBS LETTERS
Referencias:
Año: 2006 vol. 580 p. 6665 - 6668
ISSN:
0014-5793
Resumen:
Circadian entrainment involves photic stimulation of
the suprachiasmatic molecular oscillator, including activation
of the ERK/MAP kinase, which is phosphorylated endogenously
during the day and in response to light during the night. We
aimed to disrupt the diurnal cycle of ERK phosphorylation by
in vivo transfection of a constitutively active form of MEK, a
MAPK kinase. This procedure did not affect normal circadian
parameters, but completely inhibited light-induced phase advances.
Therefore, circadian regulation of the ERK pathway is
not essential for the normal mechanism of the biological clock,
but it is fundamental as an interface with environmental entrainment
by light.