Contributions of Dopaminergic Signaling to Timing Accuracy and Precision

AGOSTINO P.V.; CHENG, R.K.

Current opinion in behavioral sciences

Elsevier

Lugar: Amsterdam; Año: 2016 vol. 8 p. 153 - 160

2352-1546

Existing evidence suggests that interval timing, processing of temporal information in the hundredth of milliseconds-to-minutes range, recruits broad brain regions such as cortico-striatal circuits via dopaminergic-glutamatergic pathways. In this review, we summarize recent findings on the neurobiological basis of interval timing with a special focus on dopaminergic modulations of temporal information. Two properties of interval timing ? accuracy and precision ? are used to examine recent results from manipulations of dopaminergic signaling and the resulting distortions in temporal processing.