INVESTIGADORES
FUNDIA Ariela Freya
artículos
Título:
Chromosomal instability in chronic myeloid leukemia: Philadelphia breakpoints are independent of spontaneous breakage and fragile sites
Autor/es:
ARIELA F. FUNDIA; SUSANA H. ACEVEDO; IRENE B. LARRIPA
Revista:
HAEMATOLOGICA
Editorial:
FERRATA STORTI FOUNDATION
Referencias:
Año: 2000 vol. 85 p. 1104 - 1106
ISSN:
0390-6078
Resumen:
Chromosomal instability in chronic myeloid leukemia: Philadelphia breakpoints are independent of spontaneous breakage and fragile sites.Fundia AF, Acevedo SH, Larripa IB.Increased frequencies of spontaneous and bromodeoxyuridine induced breakages with a non-random distribution of breakpoints were found in patients with chronic myeloid leukemia, suggesting the presence of chromosome instability. Bands 9q34 or 22q11 were not damaged in these patients, demonstrating that the origin of the Philadelphia chromosome is independent of spontaneous breakage or fragile site expression.
