INVESTIGADORES
ACEBEDO SofÍa Lorena
artículos
Título:
Synthesis and biological activity of brassinosteroids fluorinated at C-2
Autor/es:
SOFÍA L. ACEBEDO; JAVIER A. RAMÍREZ; LYDIA R. GALAGOVSKY
Revista:
STEROIDS
Editorial:
ELSEVIER SCIENCE INC
Referencias:
Lugar: Amsterdam; Año: 2009 p. 435 - 440
ISSN:
0039-128X
Resumen:
In this paper we report the synthesis of four fluorinated analogues of brassinosteroids in which fluorine was introduced stereoselectively at C-2. The bioactivity of these new compounds was evaluated using the rice lamina inclination test. The results show that two of these analogues elicit high bioactivity, suggesting the involvement of hydrogen bond interactions between the active brassinosteroids and their cellular receptor.
