INVESTIGADORES
ACEBEDO SofÍa Lorena
artículos
Título:
Synthesis and biological activity of ring-A difluorinated brassinosteroids
Autor/es:
SOFÍA L. ACEBEDO; FERNANDO ALONSO; LYDIA R. GALAGOVSKY; JAVIER A. RAMÍREZ
Revista:
STEROIDS
Editorial:
ELSEVIER SCIENCE INC
Referencias:
Lugar: Amsterdam; Año: 2011 p. 1016 - 1020
ISSN:
0039-128X
Resumen:
In this paper we report the synthesis of four ring-A difluorinated analogs of brassinosteroids. The bioactivity of these new compounds was evaluated using the rice lamina inclination test. The results show that one of these analogs elicits a bioactivity comparable to that of 28-homocastasterone, a highly active natural brassinosteroid. This finding suggests that both hydroxyls at C-2 and C-3 in active brassinosteroids are involved as hydrogen bond acceptors in their interactions with the cellular receptor.
