Nonalcoholic fatty liver disease in children and adolescents - Relationship with Polycystic Ovary Syndrome.

GISELLE ADRIANA ABRUZZESE; ALICIA BEATRIZ MOTTA

CURRENT PHARMACEUTICAL DESIGN.

BENTHAM SCIENCE PUBL LTD

Lugar: Oak Park; Año: 2015

1381-6128

Nonalcoholic fatty liver disease (NAFLD) is defined as the accumulation of triglycerides (TGs) withinhepatocytes exceeding 5 % of liver weight. NAFLD is a spectrum of pathological processes from nonalcoholicfatty liver or simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma.As NAFLD induces metabolic syndrome (MS), then, NAFLD is associated with insulin resistance (IR), type2 diabetes mellitus (T2DM), hypertension and even Polycystic Ovary Syndrome (PCOS). Because it is well establishedthat patients carrying gene mutations also develop NAFLD in the absence of IR, the genetic predispositionto NAFLD is also discussed. Little is known about the diagnosis and treatment of NAFLD in children and adolescentsand the lack of non-invasive diagnostic tools in these populations is a major problem faced by physicians.The present review aims to discuss recent findings of NAFLD in children and adolescents and, considering the features in common withPCOS, we also discuss their relationship