Osteoconductivity of strontium-doped bioactive glass particles. A histomorphometric study in rats

A.A.GORUSTOVICH; T.STEIMETZ; R.L.CABRINI; J.M.PORTO LÓPEZ

Journal of Biomedical Materials Research: Part A

J. Wiley and Sons (NOTA ACEPTACIÓN EN VERSIÓN IMPRESA)

Lugar: London, UK; Año: 2008

1549-3296

There is accumulating evidence that strontium (Sr)-containing bioceramics havepositive effects on bone tissue repair. The aims of the present study were toevaluate the osteoconductivity of Sr-doped bioactive glass (BG) particlesimplanted in rat tibia bone marrow, and characterize the neoformed bone tissueby SEM-energy-dispersive X-ray microanalysis (EDX). Melt-derived BGs wereprepared from a base 45S5 BG. Sr-doped glass (45S5.6Sr) was prepared using6 wt% SrO as a substitute for the CaO. Histological analysis using undecalcifiedsections showed that new lamellar bone had formed along the surface of both45S5 and 45S5.6Sr BG particles within 4 weeks. To evaluate osteoconductivity,affinity indices were calculated. At 30d after implantation, 45S5 and 45S5.6SrBGs had almost identical affinity indices (88±7% and 87±9%; p>0.05).Strontium was not detected in the neoformed bone tissue surrounding 45S5.6SrBG particles. These results indicate that 45S5.6Sr BG particles areosteoconductive when implanted inside the intramedullary canal of rat tibiae,and no alterations in bone mineralization, in terms of Ca/P ratio, were observedin the neoformed bone tissue around 45S5.6Sr BG particles.