Milk lipid composition is modified by perinatal exposure to bisphenol A

GABRIELA A. ALTAMIRANO; MÓNICA MUÑOZ-DE-TORO; ENRIQUE H. LUQUE; AYELEN GOMEZ; MELISA B. DELCONTE; LAURA KASS

MOLECULAR AND CELLULAR ENDOCRINOLOGY.

ELSEVIER IRELAND LTD

Lugar: Amsterdam; Año: 2015

0303-7207

To evaluate whether bisphenol A (BPA) modifies the synthesis, composition and/or profile of fatty acids (FAs) in the mammary glands (MGs) of perinatally exposed animals, pregnant rats were orally exposed to 0, 0.6 or 52 µg BPA/kg/day from gestation day (GD) 9 until weaning. F1 females were bred, and on GD21, lactation day 2 (LD2) and LD10, MGs were obtained. On LD10, milk samples were collected, and FA profiles and lipid compositions were established. On GD21 and LD2, BPA exposure delayed mammary alveolar maturation and modified the synthesis of milk fat globules. On LD10, MG histo-architecture was restored; however, the milk of BPA-exposed F1 dams had a different FA profile and concentration of lipids compared with the control milk. Furthermore, the body weight gain of the BPA52 F2 pups was increased compared with the control animals. Thus, perinatal exposure to BPA modifies milk quality, compromising the normal growth of offspring.