INVESTIGADORES
SCHIJMAN Alejandro Gabriel
artículos
Título:
Molecular identification of Trypanosoma cruzi I tropism for central nervous system in Chagas reactivation due to AIDS.
Autor/es:
BURGOS JM,.; BEGHER S,; SILVA HM,; BISIO M,; DUFFY T,; LEVIN MJ; MACEDO AM,; SCHIJMAN AG
Revista:
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Editorial:
AMER SOC TROP MED & HYGIENE
Referencias:
Año: 2008 vol. 78 p. 294 - 297
ISSN:
0002-9637
Resumen:
Trypanosoma cruzi lineages, microsatellite allelic polymorphism, and mithocondrial gene haplotypes were directly typified from peripheral blood and cerebrospinal fluid specimens of a Bolivian patient with Chagas disease with accompanying AIDS and central nervous system severe involvement. Of note, the patient´s blood was infected by a mixture of T. cruzi I and T. cruzi IId/e polyclonal populations while the cerebrospinal fluid showed only a monoclonal T. cruzi I population. Our findings do not corroborate the original assumption of innocuity for T. cruzi I in the southern cone of the Americas and highlight lineage I tropism for central nervous system causing lethal Chagas reactivation