Multi-dimensional voltammetry: Four-way multivariate calibration with third-order differential pulse voltammetric data for multi-analyte quantification in the presence of unexpected interference

JALALVAND A; GHOLIVAND M; GOICOECHEA H C

CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2015 vol. 148 p. 60 - 71

0169-7439

For the first time, four-way voltammetric arrays have been produced by recording differential pulsevoltammetric (DPV) signals at different pulse heights and pulse durations. The recorded four-way arrayswere non-bilinear, trilinear and non-quadrilinear therefore, the non-linearities were tackled by potential shiftcorrection using correlation optimised warping (COW) as a well-known chemometric algorithm. Acomprehensive and systematic strategy for comparing the performances of two third-order multivariatecalibration algorithms including unfolded partial least-squares/residual trilinearization (U-PLS/RTL), andmultidimensional partial least-squares/RTL (N-PLS/RTL) which have the second-order advantage ispresented in this work, in particular with a view of practical applications. This comparison was developed toidentify which algorithm offers the best predictions for the simultaneous determination of levodopa (LD),carbidopa (CD), methyldopa (MD), acetaminophen (AC), tramadol (TRA), lidocaine (LC), tolperisone(TOP), ofloxacin (OF), levofloxacin (LOF), and norfloxacin (NOF) in the presence of benserazide (BA),dopamine (DP), and ciprofloxacin (COF) as uncalibrated interferences using a multi-walled carbonnanotubes modified glassy carbon electrode (MWCNTs/GCE). The study was employed for the discussionof the scopes of the applied third-order chemometric algorithms, demonstrating the more superiority of UPLS/RTL to resolve the complex systems. The results of applying U-PLS/RTL for the simultaneousdetermination of the studied analytes in human serum samples as experimental cases were also encouraging.