Autoradiographic evidence for beta-adrenergic receptors on capsaicin-sensitive primary afferent terminals in rat spinal cord

S.I. PATTERSON; M.R. HANLEY

NEUROSCIENCE LETTERS

Año: 1987 vol. 78 p. 17 - 21

0304-3940

Specific [3H]dihydroalprenolol binding sites are enriched in the dorsal grey matter of rat spinal cord. Neonatal capsaicin treatment, known to cause a permanent loss of a population of primary afferent neurones, caused a significant loss of specific [3H]dihydroalprenolol binding sites from laminae of the dorsal horn. These results suggest that capsaicin-sensitive primary afferent terminals may bear presynaptic beta-adrenergic receptors.