CONICET | Buscador de Institutos y Recursos Humanos

The knowledge of the underlying molecular kinetics is a key point for the development of a dialysis treatment as well as for patient monitoring. In this work, we propose a kinetic inference method that is general enough to be used on different molecular types measured in the spent dialysate. It estimates the number and significance of the compartments involved in the overall process of dialysis by means of a spectral deconvolution technique, characterizing thereforethe kinetic behavior of the patient. The method was applied to 52 patients to reveal the underlying kinetics from dialysate time-concentration profiles of urea, which has a well-known molecular kinetic. Three types of behaviors were found: onecompartmental (exponential decay Tau 180 61.64 minutes), bicompartmental (Tau1 24.96 19.33 minutes, Tau2 222.32 76.59 minutes), and tricompartmental (Tau1 23.03 14.21 minutes; Tau2 85.75 27.48 minutes; and Tau3 337 85.52 minutes). In patients with bicompartmental kinetics, the Tau2 was related to the level of dialysis dose. The study concluded that spectral deconvolution technique can be considered a powerful tool for molecular kinetics inference that could be integrated in on-line molecular analysis devices. Furthermore, the method could be used in the analysis of poorly understood molecules as well as in new hemodialysis target biomarkers. 180 61.64 minutes), bicompartmental (Tau1 24.96 19.33 minutes, Tau2 222.32 76.59 minutes), and tricompartmental (Tau1 23.03 14.21 minutes; Tau2 85.75 27.48 minutes; and Tau3 337 85.52 minutes). In patients with bicompartmental kinetics, the Tau2 was related to the level of dialysis dose. The study concluded that spectral deconvolution technique can be considered a powerful tool for molecular kinetics inference that could be integrated in on-line molecular analysis devices. Furthermore, the method could be used in the analysis of poorly understood molecules as well as in new hemodialysis target biomarkers. 180 61.64 minutes), bicompartmental (Tau1 24.96 19.33 minutes, Tau2 222.32 76.59 minutes), and tricompartmental (Tau1 23.03 14.21 minutes; Tau2 85.75 27.48 minutes; and Tau3 337 85.52 minutes). In patients with bicompartmental kinetics, the Tau2 was related to the level of dialysis dose. The study concluded that spectral deconvolution technique can be considered a powerful tool for molecular kinetics inference that could be integrated in on-line molecular analysis devices. Furthermore, the method could be used in the analysis of poorly understood molecules as well as in new hemodialysis target biomarkers.

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