INVESTIGADORES
PEREZ Ana Rosa
artículos
Título:
Cytokines and cell adhesion receptors in the regulation of immunity to Trypanosoma cruzi
Autor/es:
SAVINO W, VILLA-VERDE DMS, MENDES-DA-CRUZ DA, SILVA-MONTEIRO E, PEREZ AR, AOKI MP, BOTTASSO O, GUIÑAZU N, SILVA-BARBOSA SD, GEA S.
Revista:
Cytokine & growth factor reviews
Editorial:
Elsevier
Referencias:
Año: 2007
ISSN:
1359-6101
Resumen:
Pathophysiology of Chagas disease is not completely defined, although innate
and adaptative immune responses are crucial. In acute infection some parasite
antigens can activate macrophages, and this may result in pro-inflammatory
cytokine production, nitric oxid synthesis, and consequent control of parasitemia
and mortality. Cell-mediated immunity in T. cruzi infection is also modulated by
cytokines, but in addition to parasite-specific responses, autoimmunity can be
triggered. Importantly, cytokines also play a role in the cell-mediated immunity of
infected subjects, and the leukocyte influx towards target tissues is regulated by
cytokines/chemokines, as well as extracellular matrix components, both
representing potential therapeutic targets for a infected patients.
cytokines, but in addition to parasite-specific responses, autoimmunity can be
triggered. Importantly, cytokines also play a role in the cell-mediated immunity of
infected subjects, and the leukocyte influx towards target tissues is regulated by
cytokines/chemokines, as well as extracellular matrix components, both
representing potential therapeutic targets for a infected patients.
T. cruzi infection is also modulated by
cytokines, but in addition to parasite-specific responses, autoimmunity can be
triggered. Importantly, cytokines also play a role in the cell-mediated immunity of
infected subjects, and the leukocyte influx towards target tissues is regulated by
cytokines/chemokines, as well as extracellular matrix components, both
representing potential therapeutic targets for a infected patients.