Cytokines and cell adhesion receptors in the regulation of immunity to Trypanosoma cruzi

SAVINO W, VILLA-VERDE DMS, MENDES-DA-CRUZ DA, SILVA-MONTEIRO E, PEREZ AR, AOKI MP, BOTTASSO O, GUIÑAZU N, SILVA-BARBOSA SD, GEA S.

Cytokine & growth factor reviews

Elsevier

Año: 2007

1359-6101

Pathophysiology of Chagas disease is not completely defined, although innate and adaptative immune responses are crucial. In acute infection some parasite antigens can activate macrophages, and this may result in pro-inflammatory cytokine production, nitric oxid synthesis, and consequent control of parasitemia and mortality. Cell-mediated immunity in T. cruzi infection is also modulated by cytokines, but in addition to parasite-specific responses, autoimmunity can be triggered. Importantly, cytokines also play a role in the cell-mediated immunity of infected subjects, and the leukocyte influx towards target tissues is regulated by cytokines/chemokines, as well as extracellular matrix components, both representing potential therapeutic targets for a infected patients. cytokines, but in addition to parasite-specific responses, autoimmunity can be triggered. Importantly, cytokines also play a role in the cell-mediated immunity of infected subjects, and the leukocyte influx towards target tissues is regulated by cytokines/chemokines, as well as extracellular matrix components, both representing potential therapeutic targets for a infected patients. T. cruzi infection is also modulated by cytokines, but in addition to parasite-specific responses, autoimmunity can be triggered. Importantly, cytokines also play a role in the cell-mediated immunity of infected subjects, and the leukocyte influx towards target tissues is regulated by cytokines/chemokines, as well as extracellular matrix components, both representing potential therapeutic targets for a infected patients.