Psoriasis and cardiovascular risk: Immune-mediated crosstalk between metabolic, vascular and autoimmune inflammation

KOLLIKER FRES, RODOLFO; BISOENDIAL, R.J; MONTOYA, FABIANA; KERZKERG, E; CASTILLA, ROCÍO; TAK P.P.; MILEI, JOSÉ; CAPANI, FRANCISCO

IJC Metabolic & Endocrine

Elsevier

Año: 2015 vol. 6 p. 43 - 54

2214-7624

Introduction and Background: In the last few years, a substantial body of evidenceindicates that cutaneous psoriasis and psoriatic arthritis patients are at higher risk ofdeveloping cardiovascular disease. However, underlaying mechanism remains nocompleted understood. In this review we discuss the role of the immune system in thedevelopment of atherosclerosis, focusing on available data implicating the role of anenhanced immune-mediated pro-inflammatory status in psoriasis and psoriatic arthritisdiseases.Methods: A systematic search was performed on Pubmed until November 2014, withpreference to the sources published within the past 8 years, including epidemiologicalstudies (prospective and retrospective); cross-sectional case-control studies and reviews. .Articles were selected according critical associations using the following keywords:arthritis, immune mediated inflammatory diseases, psoriasis. These were combined withclose related keywords reflecting cardiovascular diseases: atherogenesis, endothelialdysfunction, intima media thickness, subclinical atherosclerosis, plaque, thrombosis,thrombus, fibrinolysis, coagulation, and reactive oxygen species. Both type of diseasesselected terms were separately combined with nontraditional (innate and adaptive pro andanti-inflammatory immune molecules and cells) and traditional (metabolic relatedconditions and molecules) cardiovascular risk factors.Results and conclusions: Psoriasis and psoriatic arthritis diseases illustrate that immunemediated activated crossroads of inflammation beyond enhanced cardiovascular risk factorsare the result of an interplay between different proatherogenic mediators derived frommetabolic, vascular and autoimmune joint and skin inflamed target tissue. Consistent withthis point of view, psoriasis and psoriatic arthritis diseases offer an invaluable opportunityto reinforce our knowledge about atherosclerotic cardiovascular disease.