INVESTIGADORES
GARCIA Guillermo Manuel
artículos
Título:
Differences in interactions between azole drugs related to modifications in the 14-alpha Sterol Demethylase Gene (cyp51A) of Aspergillus fumigatus.
Autor/es:
GARCÍA-EFFRON, GUILLERMO; MELLADO, EMILIA; GÓMEZ-LÓPEZ, ALICIA; ALCÁZAR-FUOLI, LAURA; CUENCA-ESTRELLA, MANUEL; RODRÍGUEZ-TUDELA, JUAN LUIS
Revista:
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Editorial:
American Society for Microbiology
Referencias:
Lugar: Washington DC (EEUU); Año: 2005 vol. 49 p. 2119 - 2121
ISSN:
0066-4804
Resumen:
The combined activity of different azole drugs was investigated. Thirty-one Aspergillus fumigatus strains were tested, including two cyp51A(-) and one cyp51B(-) gene-knockout strain and azole-susceptible and -resistant strains with different resistance mechanisms. The combination of itraconazole and voriconazole was synergistic for all strains except for those with gene knockouts.
