PERSONAL DE APOYO
BARBISAN Gisela
artículos
Título:
Fas and Fas Ligand polymorphisms in human cancer: their effect in cervical cancer
Autor/es:
PÉREZ L. O., BARBISAN G., DIFRANZA L., CONTRERAS A., AND GOLIJOW C. D.
Revista:
CURRENT TOPICS IN GENETICS
Editorial:
Research Trends
Referencias:
Año: 2011 vol. 4 p. 95 - 103
ISSN:
0972-8236
Resumen:
ABSTRACT
Apoptosis is the major component of programmed
cell death, an essential process in embryogenesis,
tissue turnover and proper function of the immune
system. Lack of appropriate control is thought to
play an important role in several pathologies, such
as autoimmune diseases, AIDS and cancer. In
malignant tumors, cells gradually acquire resistance
to apoptosis and, moreover, develop mechanisms
that could induce death cell in immune cells.
Emerging interest has given to the Fas/Fas Ligand
interaction, a system that triggers the extrinsic
pathway of the apoptosis process. Polymorphisms
on Fas and FasL have been extensively described.
Single nucleotide polymorphisms located in the
promoter region of these genes have been found
to be related to differential levels of expression.
This review discusses the information published on
Fas/Fas Ligand polymorphisms and its effect on
human cancers, and also presents new data
regarding the impact of Fas-670A/G and FasL-
844T/C polymorphisms in a cervical cancer casecontrol
study from women of La Plata, Argentina.