Histological effect of a postnatal slow release GnRH agonist on feline gonads

CARRANZA A; FAYA M; FERNÁNDEZ PE; BARBEITO CG.; GOBELLO C

THERIOGENOLOGY

ELSEVIER SCIENCE INC

Lugar: Amsterdam; Año: 2015 p. 1368 - 1372

0093-691X

In postnatal domestic cats GnRH agonists suppressed fecal concentrations of sexual steroidsand delayed puberty. The aim of this study was to describe the gross and microscopicmorphometric effects of a single administration the GnRH agonist, deslorelin acetate, on thegonads of postnatally treated cats. Twenty seven postnatal male (n= 14) and female (n= 13) kittens were randomly assigned to one of the following treatment groups within the first 24hours of birth: Deslorelin acetate 1.6 mg sc (DA; n=16) or Control which remained untreated (CO; n=11) and spayed /castrated immediately after onset of puberty. After surgical removal, the gonads were gross and histologically assessed. Sertoli cells also were examined immunohistochemically. Comparisons between treatments were carried out by Student´s t test. Gross gonadal wet weight and volume as well as gonadosomatic index weresignificantly lower in the DA than in the CO males, these same parameters were not different in females. Primordial (461.4+3.0 vs. 1074.3+117.5; P