INVESTIGADORES
MOGLIONI Albertina Gladys
artículos
Título:
Enantiodivergent synthesis of cyclobutyl (Z)-a,b-dehydro-a-amino acid derivatives from (-)-(cis)-pinononic acid
Autor/es:
G. AGUADO, A. MOGLIONI AND R. M. ORTUÑO
Revista:
TETRAHEDRON-ASYMMETRY
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 2003 vol. 14 p. 217 - 223
ISSN:
0957-4166
Resumen:
The two enantiomers of the title dehydroamino acids (DHAAs) have been synthesized through respective Wadsworth?Emmons condensations of a suitable phosphonate with enantiomeric cyclobutyl aldehydes. These compounds, in turn, were prepared by selective manipulation of the functional groups starting from (−)-cis-pinononic acid as the common chiral precursor.The CD spectra of the prepared DHAAs are described. These products are suitable for the stereocontrolled synthesis of diferent types of saturated cyclobutyl amino acids and their derivatives.
