What is known about the antiviral agents active against Bovine viral diarrhea virus (BVDV)?

LILIANA M. FINKIELSZTEIN, GRACIELA Y. MOLTRASIO, MARÍA EUGENIA CAPUTTO, ELIANA CASTRO, LUCÍA CAVALLARO AND ALBERTINA G. MOGLIONI.

CURRENT MEDICINAL CHEMISTRY.

BENTHAM SCIENCE PUBL LTD

Año: 2010 vol. 17 p. 2934 - 2955

0929-8673

Viruses belonging to the Flaviviridae family cause clinically significant diseases in humans and animals. This virus family includes three genera: Pestivirus [including bovine viral diarrhea virus (BVDV)], Flavivirus [including yellow fever (YFV), dengue, and West Nile viruses (WNV)], and Hepacivirus [including hepatitis C virus (HCV)]. BVDV is responsible for major losses in cattle, causing a range of clinical manifestations. Moreover, BVDV is a problematic contaminant in the laboratory. Noncytopathic BVDV infection can remain unnoticed and infects laboratory cell lines through its presence in contaminated bovine serum used in cell culture. BVDV is considered to be a valuable surrogate virus model for identifying and characterizing antiviral agents for using against HCV. In some aspects of viral replication, BVDV is more advantageous than the currently used HCV replicon systems. In this review we report the design, synthesis, and activity against BVDV of a series of compounds assayed until now.