INVESTIGADORES
BARAVALLE Maria Eugenia
artículos
Título:
Altered expression of proinflammatory cytokines in ovarian follicles of cows with cystic ovarian disease.
Autor/es:
BARAVALLE M.E; STASSI A; VELÁZQUEZ MML; BELOTTI M; RODRÍGUEZ FM; ORTEGA H.H.; SALVETTI NR
Revista:
JOURNAL OF COMPARATIVE PATHOLOGY
Editorial:
ELSEVIER SCI LTD
Referencias:
Lugar: Amsterdam; Año: 2015
ISSN:
0021-9975
Resumen:
A growing body of evidence suggests that ovulation shares many of the features of an inflammatory reaction
and that cytokines play many diverse and important roles in reproductive biology. The aim of this study
was to examine the expression of the pro-inflammatory cytokines interleukin (IL)-1a, IL-6 and tumour necrosis
factor (TNF)-a in ovarian cells from cows with cystic ovarian disease (COD) as compared with that in
ovarian structures from regularly cycling cows. Expression of genes encoding IL-1a, IL-6 and TNF-a was detected
by real-time polymerase chain reaction in follicular cells from ovaries from healthy cows and cows with
COD with no significant differences. However, immunohistochemistry showed increased expression of IL-1a,
IL-6 and TNF-a in cystic follicles, suggesting that this expression may be related to the persistence of follicular
cysts. The effect of COD was evident for IL-1a and TNF-a, and a follicular structureedisease interaction was
observed in the expression of all the cytokines evaluated. Thus, altered expression of these proinflammatory
cytokines may be related to ovulation failure and development of follicular cysts.