INVESTIGADORES
ENRIZ Ricardo Daniel
artículos
Título:
New Antitumoral Acetogenin Guanacone type Derivatives: Isolation and Bioactivity. Molecular Dynamics Simulation of Diacetyl-guanacone
Autor/es:
I.BARRACHINA,I.ROYO,H.A.BALDONI, N. CHARBOUNE, F.SUVIRE, N.DEPEDRO,M.C.ZAFRA-POLO, A.BERMEJO, N.CABEDO, J.SAEZ.,J.TORMO, R.D.ENRIZ, D.CORTES
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY.
Editorial:
Elsevier
Referencias:
Lugar: Amsterdam; Año: 2007 vol. 15 p. 4369 - 4381
ISSN:
0968-0896
Resumen:
AbstractWe describe herein the isolation and semisynthesis of four acetogenin derivatives (14) as well as their ability to inhibit
the mitochondrial respiratory chain and several tumor cell lines. In addition, four nanoseconds (ns) of MD simulation of compound
the mitochondrial respiratory chain and several tumor cell lines. In addition, four nanoseconds (ns) of MD simulation of compound
We describe herein the isolation and semisynthesis of four acetogenin derivatives (14) as well as their ability to inhibit
the mitochondrial respiratory chain and several tumor cell lines. In addition, four nanoseconds (ns) of MD simulation of compound
4, in a fully hydrated POPC bilayer, is reported., in a fully hydrated POPC bilayer, is reported.